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Lithocholic Acid
(CAS RN:434-13-9 Product Number:L0089)

Structure

Lithocholic Acid
Synonym 5β-Cholanic Acid-3α-ol
Synonym 3α-Hydroxy-5β-cholanic Acid

General Information

Product Number L0089

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Purity/Analysis Method >98.0%(T)
Storage Temperature
M.F. / M.W. C24H40O3=376.58
CAS RN 434-13-9
Related CAS RN
MDL Number MFCD00003682
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(GC) min. 97.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 185.0 to 190.0 deg-C
Specific rotation [a]20/D +33.0 to +38.0 deg(C=1, EtOH)

References

Beilstein 10(3)687
Reaxys-RN 3217757
PubChem SID 87572051
Merck Index(14) 5545
RTECS# FZ2275000
EC Number 207-099-1

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2918199890

Application

Lithocholic acid: A Monohydroxy Secondary Bile Acid

Lithocholic acid is a monohydroxy secondary bile acid that acts as a detergent to solubilize fats for absorption. It is formed in the colon by bacterial 7-dehydroxylation of the primary bile acid chenodeoxycholic acid (CDCA) [C0750] and of the secondary bile acid ursodeoxycholic acid (UDCA) [U0030]. Recently, lithocholic acid is identified as an endogenous ligand of the vitamin D receptor (VDR) and a pregnane X receptor (PXR) activator. Lithocholic acid has been used for several therapeutic purposes in man. (The product is for research purpose only.)

References

PubMed Literature

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