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Tacrolimus Monohydrate
(CAS RN:109581-93-3 Product Number:M2258)

Structure

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Tacrolimus
Synonym FK 506 Monohydrate

General Information

Product Number M2258

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Purity/Analysis Method >80.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C44H69NO12·H2O=822.05
CAS RN 109581-93-3
Related CAS RN 104987-11-3
MDL Number MFCD11045918
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Appearance White to Almost white powder to crystal
Purity(HPLC) min. 80.0 area%
Melting point 125.0 to 129.0 deg-C

References

Reaxys-RN 6265275
PubChem SID 160871186
Merck Index(14) 9025
RTECS# KD4201200

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2934999090

Application

Tacrolimus: A Calcineurin Inhibitor with Immunosuppressive Properties

Tacrolimus, known as FK506, is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. Tacrolimus is practically insoluble in water, freely soluble in ethanol and DMF, and very soluble in methanol and chloroform. Tacrolimus inhibits T-lymphocyte activation, although the exact mechanism of action is not known. Experimental evidence suggests that tacrolimus is inactive by itself and requires binding to an intracellular protein, FK506 binding protein-12 (FKBP-12), for activation in cells. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin (a calcium and calmodulin dependent protein phosphatase) is then formed and the phosphatase activity of calcineurin inhibited. This effect may prevent both T-lymphocyte signal transduction and IL-2 transcription. Cyclosporin A [C2408] also inhibits calcineurin but is less potent than tacrolimus. Tacrolimus is mainly metabolized by cytochrome P 450 IIIA (CYP3A) subfamilies. (The product is for research purpose only.)

References

PubMed Literature

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