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Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)
(CAS RN:429-41-4 Product Number:T1338)

Structure

Tetrabutylammonium Fluoride
Synonym TBAF (ca. 1mol/L in Tetrahydrofuran)

General Information

Product Number T1338

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Purity/Analysis Method
Storage Temperature 0-10°C
M.F. / M.W. C16H36FN=261.47
CAS RN 429-41-4
Related CAS RN
MDL Number MFCD00011747
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Concentration(Nonaqueous Titration) 1.0 to 1.1 mol/L
Density(20deg.C) 0.9100 to 0.9300 g/mL
Water max. 10.0 %
TBHF-HF(neutralization titration) max. 5.0 %

Data of Reference

flp -17°C(lit.)

References

Beilstein 4(4)557
Reaxys-RN 3570522
PubChem SID 87577107
Merck Index(14) 9187
F&F 12,458

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H225
  • :Highly flammable liquid and vapor.
  • H302
  • :Harmful if swallowed.
  • H314
  • :Causes severe skin burns and eye damage.
  • H335
  • :May cause respiratory irritation.
  • H371
  • :May cause damage to Nervous System.
  • H372
  • :Causes damage to Liver, Nervous System, Kidney through prolonged or repeated exposure.
Precautionary Statements
  • P210
  • :Keep away from heat, sparks, open flames and hot surfaces. – No smoking.
  • P233
  • :Keep container tightly closed.
  • P240
  • :Ground and bond container and receiving equipment.
  • P241+P242+P243
  • :Use explosion-proof electrical, ventilating and lighting equipment. Use only non-sparking tools. Take precautionary measures against static discharge.
  • P260
  • :Do not breathe mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P271
  • :Use only outdoors or in a well-ventilated area.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P330+P331+P310
  • :If swallowed: Rinse mouth. Do NOT induce vomiting. Immediately call a poison center or doctor.
  • P303+P361+P353+P310+P363
  • :If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a poison center or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. Immediately call a poison center or doctor.
  • P305+P351+P338+P310
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center or doctor.
  • P308+P311
  • :If exposed or concerned: Call a poison center or doctor.
  • P403+P233
  • :Store in a well-ventilated place. Keep container tightly closed.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2924
Class 3/8
Packing Group II

Application

Generation of Benzyne and Reaction with Furan

T1338

References

Synthesis of β,β-Difluorohomoallylic Alcohols

Typical Procedure:
Under an argon atmosphere, TBAF (1.0 M in THF, 1.5 mL, 1.5 mmol) is added into a suspension of flame-dried MS4Å (1.0 g) in THF (4.0 mL) and the mixture is stirred at room temperature for 2.0 h. Then the mixture is cooled at -20 °C and a solution of ethyl 4,4-difluoro-3-(triethylsilyl)but-3-enoate (265 mg, 1.0 mmol) and benzaldehyde (204 µL, 2.0 mmol) is added to the mixture over 1.0 h at -20 °C. After stirring the mixture for
1 h at the same temperature, the whole is poured into aqueous 10% HCl, extracted with Et2O and the organic layer is dried with anhydrous MgSO4. After evaporation of the solvent, the residue is purified by column chromatography (SiO2, EtOAc : hexane) to give the desired product.

References

PubMed Literature

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