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Aminopterin Hydrate
(CAS RN:54-62-6 Product Number:A0410)


Synonym 4-Aminofolic Acid Hydrate
Synonym 4-Amino-PGA Hydrate
Synonym 4-Aminopteroyl-L-glutamic Acid Hydrate

General Information

Product Number A0410

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Purity/Analysis Method >97.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C19H20N8O5·xH2O=440.42(as Anhydrous)
CAS RN 54-62-6
Related CAS RN
MDL Number MFCD00036692
Packaging and Container
  • Product Details
  • Safety & Regulations


Purity(HPLC) min. 97.0 area%
Purity(Neutralization titration) min. 97.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +18.0 to +22.0 deg(C=1、0.1mol/LNaOH sol.)(calcd.on anh.substance)
Water 3.0 to 10.0 %


Reaxys-RN 69045
PubChem SID 125308158
Merck Index(14) 472
RTECS# MA1050000
EC Number 200-209-9


Signal Word Danger
Hazard Statements
  • H300
  • :Fatal if swallowed.
  • H360FD
  • :May damage fertility. May damage the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.

Transport Information

UN Number 2811
Class 6.1
Packing Group I
HS Number 2933599590


Aminopterin: A Dihydrofolic Acid Reductase (DHFR) Inhibitor

Aminopterin, an amino derivative of folic acid [F0043], is a dihydrofolic acid reductase (DHFR) inhibitor. DHFR is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using nicotinamide adenine dinucleotide phosphate (NADPH) as electron donor, and a key enzyme in the synthesis of thymidylate and DNA. The inhibition causes the depletion of nucleotide precursors and inhibition of DNA. Aminopterin used to use as an antineoplastic agent in the treatment of leukemia. In the 1950’s, a less potent but less toxic methotrexate [M1664] began to replace in clinical use. (The product is for research purpose only.)


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