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Azathioprine
(CAS RN:446-86-6 Product Number:A2069)

Structure

Azathioprine
Synonym 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine

General Information

Product Number A2069

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature <0°C
M.F. / M.W. C9H7N7O2S=277.26
CAS RN 446-86-6
Related CAS RN
MDL Number MFCD00069203
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %

Data of Reference

mp 244°C(dec.)(lit.)

References

Reaxys-RN 1225351
PubChem SID 87559964
Merck Index(14) 902
RTECS# UO8925000
EC Number 207-175-4

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
  • H350
  • :May cause cancer.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.

Transport Information

HS Number 2933998090

Application

Azathioprine: An Inhibitor of Purine Ribonucleotides and DNA/RNA Synthesis

A2069

Azathioprine, a prodrug of 6-mercaptopurine (6-MP) [M0063], was developed by Elion and Hitchings as an immunosuppressant agent for renal transplantation in 1962. They shared the Nobel Prize in 1988. In cell, 6-MP is converted to 6-thioinosine monophosphate (TIMP), catalyzed by hypoxanthine guanine phosphoribosyltransferase (HPRT). TIMP inhibits conversion of inosinic acid to adenylosuccinic acid and xanthylic acid, subsequently leading to inhibition of purine ribonucleotides and DNA/RNA synthesis. Azathioprine and 6-MP are commonly used as an immunosuppressant for treatment of rheumatism, Crohn’s disease and inflammatory bowel disease. (The product is for research purpose only.)

References

PubMed Literature

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