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DBD-F [=4-(N,N-Dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole] [for HPLC Labeling]
(CAS RN:98358-90-8 Product Number:A5595)


Synonym 4-(N,N-Dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole
Synonym 7-Fluoro-4-(N,N-dimethylaminosulfonyl)benzofurazan
Synonym 7-Fluoro-4-(N,N-dimethylsulfamoyl)-2,1,3-benzoxadiazole

General Information

Product Number A5595

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C8H8FN3O3S=245.23
CAS RN 98358-90-8
Related CAS RN
MDL Number MFCD00143356
Packaging and Container
  • Product Details
  • Safety & Regulations


Purity(HPLC) min. 98.0 area%
Melting point 124.0 to 128.0 deg-C
Effect test of HPLC derivatization Effective as labeling agent for L-Valine.


Reaxys-RN 8142578
PubChem SID 87563202


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2935909099


HPLC Labeling Reagent for Amines and Thiols

The compound 1 which is an HPLC fluorescence labeling reagent having a 2,1,3-benzoxadiazole skeleton, can easily react with amino and mercapto groups to form the corresponding derivatives. The derivatives are stable enough to reach the detector without any decomposition under reversed phase HPLC. An excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 450 nm and 590 nm, respectively.

Application example:
[Amino acids]
0.5 mL of 20 mM labeling reagent in acetonitrile is put into an amber-glass vial. To this solution, add 0.5 mL of 0.1 M boric acid buffer solution (pH 9.3, containing 1mM EDTANa2) containing several nmol of an amino acid, and incubate at 50 ºC for 30 min. After cooling the reaction mixture with ice bath, use it as an HPLC sample.
For example, the detection limit (S/N=3) for proline is 0.11 pmol.


PubMed Literature

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