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Dolasetron Mesylate Monohydrate
(CAS RN:878143-33-0 Product Number:D5481)

Structure

Dolasetron Mesylate
Synonym Dolasetron Methanesulfonate Monohydrate

General Information

Product Number D5481

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature
M.F. / M.W. C19H20N2O3·CH4O3S·H2O=420.48(as Anhydrous)
CAS RN 878143-33-0
Related CAS RN 115956-13-3
MDL Number MFCD01718979
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 6.10 to 6.70 %
Water 3.0 to 5.0 %

References

Reaxys-RN 8461425
Merck Index(14) 3411
RTECS# NL6015300

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2933998090

Application

Dolasetron Mesylate: A Selective Serotonin Subtype 3 (5-HT3) Receptor Antagonist

Dolasetron mesylate is a selective serotonin subtype 3 (5-HT3) receptor antagonist. It is rapidly converted in vivo to its active major metabolite, hydrodolasetron, which appears to be largely responsible for its pharmacological activity. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, selective 5-HT3 receptor antagonists, dolasetron, granisetron [G0401], ondansetron [O0407] and tropisetron [T2743] are used for the prevention of chemotherapy-induced nausea and vomiting, but they have been reported to be associated with QTc prolongation. (The product is for research purpose only.)

References

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