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Mequitazine
(CAS RN:29216-28-2 Product Number:M2807)

Structure

Mequitazine
Synonym 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
Synonym 10-(Quinuclidin-3-ylmethyl)-10H-phenothiazine

General Information

Product Number M2807

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Purity/Analysis Method >98.0%(GC)(T)
Storage Temperature
M.F. / M.W. C20H22N2S=322.47
CAS RN 29216-28-2
Related CAS RN
MDL Number MFCD01706743
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 146.0 to 150.0 deg-C

References

Reaxys-RN 1150945
PubChem SID 354333324
Merck Index(14) 5864
RTECS# SP5080000
EC Number 249-521-7

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2934309090

Application

Mequitazine: A Long-Acting and Selective Histamine H1-Receptor Antagonist

Mequitazine is a long-acting and selective histamine H1-receptor antagonist. Mequitazine also possesses antagonistic activity for leukotrienes (LTs) and platelet activating factor (PAF). In the inhibition process, mequitazine acts to inhibit the Ca2+ release from intracellular calcium store of mast cells. Mequitazine is mainly biotransformed by cytochrome P450 2D6 (CYP2D6) in human liver to yield aromatic hydroxylated and S-oxidized metabolites.

References

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