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Roflumilast N-Oxide
(CAS RN:292135-78-5 Product Number:R0217)

Structure

Roflumilast N-Oxide
Synonym 3,5-Dichloro-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamido]pyridine 1-Oxide

General Information

Product Number R0217

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C17H14Cl2F2N2O4=419.21
CAS RN 292135-78-5
Related CAS RN
MDL Number MFCD04112984
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 6.00 to 7.00 %
Melting point 179.0 to 183.0 deg-C

References

Reaxys-RN 10715186

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2933399990

Application

Roflumilast N-Oxide: An Active Metabolite of Roflumilast, a Selective Phosphodiesterase 4 (PDE4) Inhibitor

Roflumilast N-oxide is an active metabolite of roflumilast [R0193] which is a selective phosphodiesterase 4 (PDE4) inhibitor. PDE4 is a key enzyme in the degradation of cyclic adenosine monophosphate (cyclic AMP) [A2381] and is centrally involved in the cytokine production of inflammatory cells. The inhibition of PDE4 activity leads to accumulation of intracellular cyclic AMP. Roflumilast N-oxide is also used for the treatment of chronic obstructive pulmonary disease (COPD). While the precise mechanism of the therapeutic action in COPD is not well defined, it is thought to be related to the effects of increased intracellular cyclic AMP in lung cells. (The product is for research purpose only.)

References

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