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Sertindole
(CAS RN:106516-24-9 Product Number:S0942)

Structure

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Sertindole
Synonym 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone

General Information

Product Number S0942

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Purity/Analysis Method >95.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C24H26ClFN4O=440.95
CAS RN 106516-24-9
Related CAS RN
MDL Number MFCD00867749
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 95.0 area%
Elemental analysis(Nitrogen) 12.00 to 13.00 %

Data of Reference

mp 155°C(lit.)

References

Reaxys-RN 5364890
PubChem SID 253660923
Merck Index(14) 8466
RTECS# NJ0621100

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2933399990

Application

Sertindole: An Antagonist at Dopamine D2, Serotonin 5-HT2A2C, and α1-Adrenergic Receptors

Sertindole is an antipsychotic with high affinity for and functions as an antagonist at a number of receptor systems, including dopamine D2 receptors, serotonin 5-HT2A and 5-HT2C receptors, and α1-adrenergic receptors, and low affinity for other receptors. Sertindole undergoes extensive hepatic metabolism by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4 and has an elimination half-life of approximately three days. On the other hand, sertindole can prolong the Q-T interval which is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.

References

PubMed Literature

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