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Zolmitriptan
(CAS RN:139264-17-8 Product Number:Z0024)

Structure

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Zolmitriptan
Synonym (S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone

General Information

Product Number Z0024

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C16H21N3O2=287.36
CAS RN 139264-17-8
Related CAS RN
MDL Number MFCD00871503
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 136.0 to 140.0 deg-C
Specific rotation [a]20/D -3.0 to -5.0 deg(C=1、MeOH)

Data of Reference

λmax 225(lit.)

References

Reaxys-RN 7415010
PubChem SID 253659590
Merck Index(14) 10189
RTECS# RQ2707000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2934999090

Application

Zolmitriptan: A Selective 5-HT1B/1D Receptor Agonist

Zolmitriptan is a selective 5-HT1B/1D receptor agonist, belongs to triptans. Zolmitriptan binds with high affinity to 5-HT1 receptor subtypes (5-HT1B, 5-HT1D), and moderate affinity for a serotonergic receptor subtype (5-HT1A). Zolmitriptan is mainly metabolized by CYP1A2 to an initial metabolite N-desmethylzolmitriptan which also has high affinity for 5-HT1B/1D and moderate affinity for 5-HT1A receptors. Animal studies shows that zolmitriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system. (The product is for research purpose only.)

References

PubMed Literature

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