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Dirithromycin
(CAS RN:62013-04-1 Product Number:D5495)

Structure

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Dirithromycin
Synonym [9S(R)]-9-Deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)ethylidene]oxy]erythromycin
Synonym LY-237216

General Information

Product Number D5495

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Purity/Analysis Method >98.0%(HPLC)(N)
Storage Temperature 0-10°C
M.F. / M.W. C42H78N2O14=835.09
CAS RN 62013-04-1
Related CAS RN
MDL Number MFCD00865041
Packaging and Container
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Specification

Purity(HPLC)(CAD) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 186.0 to 190.0 deg-C
Specific rotation [a]20/D -85.0 to -90.0 deg(C=1, MeOH)

References

Reaxys-RN 6842524
Merck Index(14) 3354
RTECS# JG5806477

Transport Information

HS Number 2941500000

Application

Dirithromycin: A Macrolide Antibiotic with Outstanding Activity against Campylobacter

Dirithromycin is a macrolide antibiotic derived from erythromycin [E0751]. Dirithromycin is a prodrug, and is hydrolyzed in vivo to its major active metabolite, erythromycilamine.1) Although the antimicrobial spectrum of dirithromycin is similar to that of erythromycin, it reportedly has outstanding activity against Campylobacter.2) In addition, erythromycin inhibits cytochrome P450 isoform 3A4 (CYP3A4), but dirithromycin and azithromycin [A2076] neither inhibit CYP3A4 nor are implicated in clinically significant drug-drug interactions.3) (The product is for research purpose only.)

References

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