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Fludarabine Monophosphate
(CAS RN:75607-67-9 Product Number:F0913)

Structure

Fludarabine Monophosphate
Synonym 9-(β-D-Arabinofuranosyl)-2-fluoroadenine 5'-Monophosphate
Synonym 2-F-ara-AMP
Synonym 2-Fluoroadenine 9-β-D-Arabinofuranoside 5'-Monophosphate

General Information

Product Number F0913

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C10H13FN5O7P=365.21
CAS RN 75607-67-9
Related CAS RN
MDL Number MFCD00866418
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D +11.0 to +13.0 deg(C=0.5, H2O)

Data of Reference

mp 203°C(dec.)(lit.)

References

Reaxys-RN 8167686
PubChem SID 253660324
Merck Index(14) 4126
RTECS# UO7440900

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
  • H362
  • :May cause harm to breast-fed children.
  • H373
  • :May cause damage to Eye through prolonged or repeated exposure.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P260
  • :Do not breathe dust, fume, mist, vapours or spray.
  • P263
  • :Avoid contact during pregnancy/while nursing.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.

Transport Information

HS Number 2934999090

Application

Fludarabine phosphate (2-F-ara-AMP): An Inhibitor of DNA Synthesis

Fludarabine phosphate (2-F-ara-AMP) is an adenine nucleoside analog that is converted first to 9-β-D-arabinofuranosyl-2-fluoradenine (2-F-ara-A) and then into the active metabolite 2-F-ara-A triphosphate (F-ara-ATP). The triphosphate inhibits the synthesis of primer RNA and DNA by DNA polymerase primase complex, and also induces cell death through apoptosis. Fludarabine phosphate shows activity against chronic lymphocytic leukemia (CLL) and indolent lymphoma. (The product is for research purpose only.)

References

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