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Leucomycins
(CAS RN:1392-21-8 Product Number:K0046)

Structure

Leucomycins
Synonym Kitasamycin

General Information

Product Number K0046

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Purity/Analysis Method
Storage Temperature
M.F. / M.W.
CAS RN 1392-21-8
Related CAS RN
MDL Number MFCD00147435
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 48.0area% (A5+A4+A1)
Leucomycin A5 40.0 to 70.0 area%
Leucomycin A4 5.0 to 25.0 area%
Leucomycin A1 3.0 to 12.0 area%
Water max. 3.0 %

References

PubChem SID 87560725
Merck Index(14) 5453
RTECS# OH4550000

Transport Information

HS Number 2941900000

Application

Leucomycin (kitasamycin): A Mixture of 16-Membered Macrolide Substances Having Antibacterial Activity

Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Leucomycin (other name: kitasamycin) is a mixture of 16-membered macrolide substances having antibacterial activity isolated from the broth filtrate of Streptomyces kitasatoensis. It has activity against Gram-positive bacteria, some Gram-negative bacteria, spirochetes, and rickettsiae. It inhibits bacterial protein synthesis both in vivo and in vitro. Recently, renewed interest in synthesis of 16-membered macrolide derivatives has been evoked by their interesting properties.

References

PubMed Literature

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