Home >   Products   >  Advanced Search

Meclizine Dihydrochloride
(CAS RN:1104-22-9 Product Number:M2755)


Meclizine Dihydrochloride
Synonym 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine Dihydrochloride

General Information

Product Number M2755

* Items available from stock in Japan will be delivered in 10 business days.
* Please contact us if you need further information.
(Sales Dept Tel: +32 (0)3 735 07 00 E-mail: Sales-EU@TCIchemicals.com)
* To send your quote request for bulk quantities, please click on the “Request Bulk Quotation” button. Please note that for some of our products we cannot offer bulk quantities.
* TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C25H27ClN2·2HCl=463.87
CAS RN 1104-22-9
Related CAS RN 569-65-3
MDL Number MFCD00058199
Packaging and Container
  • Product Details
  • Safety & Regulations


Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 95.0 %
Melting point 210.0 to 214.0 deg-C


Reaxys-RN 3798111
PubChem SID 253661196
RTECS# TL2005000
EC Number 214-164-8


Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.

Transport Information

HS Number 2933599590


Meclizine Hydrochloride: A Piperazine Class of Histamine H1 Receptor Antagonists

Meclizine hydrochloride, a piperazine class of histamine H1 receptor antagonists, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine also has anticholinergic activity probably because of its dopamine receptors antagonist activities. In addition, meclizine has been reported to be an inverse agonist of constitutive androstane receptor (CAR). Based on studies conducted on rats, meclizine undergoes extensive hepatic metabolism to an inactive metabolite, norchlorcyclizine or 1-(4-chlorobenzhydryl)piperazine [C1611]. Meclizine hydrochloride is a poorly water-soluble agent having a very slow-onset of action. Therefore, the water solubility enhancement of meclizine hydrochloride has been studied.


PubMed Literature

Page Top