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Meclizine Dihydrochloride
(CAS RN:1104-22-9 Product Number:M2755)

Structure

Meclizine Dihydrochloride
Synonym 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine Dihydrochloride

General Information

Product Number M2755

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C25H27ClN2·2HCl=463.87
CAS RN 1104-22-9
Related CAS RN 569-65-3
MDL Number MFCD00058199
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 95.0 %
Melting point 210.0 to 214.0 deg-C

References

Reaxys-RN 3798111
PubChem SID 253661196
RTECS# TL2005000
EC Number 214-164-8

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H361fd
  • :Suspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.

Transport Information

HS Number 2933599590

Application

Meclizine Hydrochloride: A Piperazine Class of Histamine H1 Receptor Antagonists

Meclizine hydrochloride, a piperazine class of histamine H1 receptor antagonists, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine also has anticholinergic activity probably because of its dopamine receptors antagonist activities. In addition, meclizine has been reported to be an inverse agonist of constitutive androstane receptor (CAR). Based on studies conducted on rats, meclizine undergoes extensive hepatic metabolism to an inactive metabolite, norchlorcyclizine or 1-(4-chlorobenzhydryl)piperazine [C1611]. Meclizine hydrochloride is a poorly water-soluble agent having a very slow-onset of action. Therefore, the water solubility enhancement of meclizine hydrochloride has been studied.

References

PubMed Literature

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