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Norfloxacin
(CAS RN:70458-96-7 Product Number:N0817)

Structure

Norfloxacin
Synonym 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid

General Information

Product Number N0817

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C16H18FN3O3=319.34
CAS RN 70458-96-7
Related CAS RN
MDL Number MFCD00079532
Packaging and Container
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

Data of Reference

mp 221°C(lit.)

References

Beilstein 23(5)3,135
Reaxys-RN 567897
PubChem SID 125307523
Merck Index(14) 6700
RTECS# VB2005000
EC Number 274-614-4

Transport Information

HS Number 2933599590

Application

Norfloxacin: The First Fluoroquinolone Antibacterial Reagent

Norfloxacin is the first fluoroquinolone antibacterial reagent which is synthesized from [C2897] with piperazine. Its structure is related to nalidixic acid [N0490] but its potency has been increased by a fluorine atom and by a piperazine moeity. Thereby, norfloxacin has a broad spectrum of activity against both Gram-positive bacteria and Gram-negative bacteria. Norfloxacin and the other fluoroquinolones inhibit bacterial DNA synthesis by inhibiting the enzyme gyrase which catalyzes the operations of the DNA double strand such as opening, under winding, and closing. Fluoroquinolones appear to prevent specifically the resealing of opened DNA strands and thereby act bactericidally.

References

PubMed Literature

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