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Trimethyl Orthoformate
(CAS RN:149-73-5 Product Number:O0068)


Trimethyl Orthoformate
Synonym Methyl Orthoformate
Synonym Orthoformic Acid Trimethyl Ester
Synonym Trimethoxymethane

General Information

Product Number O0068

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Purity/Analysis Method >98.0%(GC)
Storage Temperature
M.F. / M.W. C4H10O3=106.12
CAS RN 149-73-5
Related CAS RN
MDL Number MFCD00008483
Packaging and Container
  • Product Details
  • Safety & Regulations


Appearance Colorless to Almost colorless clear liquid
Purity(GC) min. 98.0 %
Specific gravity (20/20) 0.9680 to 0.9720
Refractive index n20/D 1.3770 to 1.3800

Data of Reference

flp 15°C(lit.)
bp 100°C


Beilstein 2,19
Reaxys-RN 969215
PubChem SID 87574082
Merck Index(14) 6884
F&F 10,425
RTECS# RM6650000
EC Number 205-745-7


Signal Word Danger
Hazard Statements
  • H225
  • :Highly flammable liquid and vapour.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P210
  • :Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
  • P280
  • :Wear protective gloves, eye protection.
  • P303+P361+P353
  • :IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P370+P378
  • :In case of fire: Use dry chemical or dry sand to extinguish.
  • P403+P235
  • :Store in a well-ventilated place. Keep cool.

Transport Information

UN Number 3272
Class 3
Packing Group II
HS Number 2915130090


MOM protection of Diols using Trimethyl Orthoformate


  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

N-Formylation of Amino Acid Esters



PubMed Literature

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