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Arotinolol Hydrochloride
(CAS RN:68377-91-3 Product Number:A3145)

Structure

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Arotinolol Hydrochloride
Synonym 5-[2-[[3-(tert-Butylamino)-2-hydroxypropyl]thio]thiazol-4-yl]thiophene-2-carboxamide Hydrochloride

General Information

Product Number A3145

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C15H21N3O2S3·HCl=407.99
CAS RN 68377-91-3
Related CAS RN 68377-92-4
MDL Number MFCD00941421
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %

Data of Reference

mp 236°C(dec.)(lit.)

References

Reaxys-RN 10042125
PubChem SID 354335253
Merck Index(14) 791
RTECS# XM8301000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :If swallowed: Immediately call a poison center or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2811
Class 6.1
Packing Group III

Application

Arotinolol Hydrochloride: A β-Adrenoceptor Antagonist

Arotinolol hydrochloride (S-596), β-adrenoceptor antagonist, shows high affinities for both β1- and β2-adrenoceptors. Reportedly, It shows a moderate affinity also for α-adrenoceptor, and the mean ratio of α:β = 1:8. In addition, its main metabolite (the 2-thiophenecarboxylic acid, AC-623) also shows affinity for β-adrenoceptors. Arotinolol is widely used in the treatment of high blood pressure. (The product is for research purpose only.)

References

PubMed Literature

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