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Cefoxitin Sodium
(CAS RN:33564-30-6 Product Number:C3602)

Structure

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Cefoxitin Sodium
Synonym Sodium (6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

General Information

Product Number C3602

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C16H16N3NaO7S2=449.43
CAS RN 33564-30-6
Related CAS RN
MDL Number MFCD00079042
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 202.0 to 206.0 deg-C
Specific rotation [a]20/D +206 to +214 deg(C=1, MeOH)

Data of Reference

λmax 260(H2O)(lit.)

References

Reaxys-RN 4104290
Merck Index(14) 1936
RTECS# XI0330500

Application

Cefoxitin Sodium: A Second Generation Cephem Antibiotic against beta-Lactamase

Cefoxitin sodium and its free acid [C3598] are semi-synthetic antibiotic that are derived from cephamycin C which is produced by Streptomyces lactamdurans. Cefoxitins have bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria including aerobes and anaerobes.1,2) Cefoxitins are second generation cephem antibiotics which act by inhibition bacterial cell wall synthesis. Due to the presence of a 7-α methoxy group in the β-lactam ring, cefoxitins exhibit a high degree of stability in the presence of beta-lactamases.1,3)

References

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