Home >   Products   >  Advanced Search

Potassium [[(tert-Butoxycarbonyl)amino]methyl]trifluoroborate
(CAS RN:1314538-55-0 Product Number:P2155)


Potassium [[(tert-Butoxycarbonyl)amino]methyl]trifluoroborate
Synonym Potassium (N-Boc-aminomethyl)trifluoroborate

General Information

Product Number P2155

* INR price is exclusive of domestic taxes applicable.
* USD price is only applicable to SEZ and/or EOU licence holders.
* Items available in Chennai warehouse will be dispatched within 24 hours upon orders.
* Items available in Japan warehouse will be dispatched within 2-3 calendar weeks upon orders.
* To send your quote request for bulk quantities, please click on the “Request Bulk Quotation” button. Please note that we cannot offer bulk quantities for some products.
* TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

Purity/Analysis Method >97.0%(N)
Storage Temperature
M.F. / M.W. C6H12BF3KNO2=237.07
CAS RN 1314538-55-0
Related CAS RN
MDL Number MFCD19686142
Packaging and Container


This material was produced by collaboration with Eisai Co., Ltd. (Patent No. WO2008007670)
  • Product Details
  • Safety & Regulations


Purity(with Total Nitrogen) min. 97.0 %

Data of Reference

mp 181°C(lit.)


Reaxys-RN 21751374
PubChem SID 253661860


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.


Introduction of an aminomethyl group by Suzuki-Miyaura cross-coupling reaction


General Procedure for the Suzuki?Miyaura Cross-coupling Reaction: A sealed tube is charged with potassium (tert-butoxycarbonyl)amino)methyl)trifluoroborate (62 mg, 0.263 mmol, 1.05 equiv), an aryl or heteroaryl chloride (0.25 mmol, 1.0 equiv), Pd(OAc)2 (3 mg, 0.013 mmol, 0.05 equiv), SPhos ligand (0.03 mmol, 0.1 equiv) and K2CO3 (104 mg, 0.75 mmol, 3.0 equiv). The mixture is then purged with argon. Toluene/H2O (4:1, 0.8 mL / 0.2 mL) is then added to the reaction tube. The reaction mixture is stirred for 22 h at 85 °C and then cooled to rt. A solution of pH 7 buffer (2 mL) is added, and the resulting mixture is extracted with EtOAc (2 × 3 mL). The organic layer is combined, dried (MgSO4) and filtered. The solvent is removed in vacuo and the product is purified by column chromatography to give the corresponding compound in shown yield.


Page Top