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Tubastatin A Hydrochloride
(CAS RN:1310693-92-5 Product Number:T3687)

Structure

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Tubastatin A Hydrochloride
Synonym N-Hydroxy-4-[[2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl]methyl]benzamide Hydrochloride

General Information

Product Number T3687

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Purity/Analysis Method >97.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C20H21N3O2·HCl=371.87
CAS RN 1310693-92-5
Related CAS RN
MDL Number MFCD20488052
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Specification

Purity(HPLC) min. 97.0 area%
Elemental analysis(Nitrogen) 10.70 to 11.90 %

References

Reaxys-RN 27221763

Transport Information

HS Number 2933998090

Application

Tubastatin A Hydrochloride: A Potent Histone Deacetylase (HDAC) 6 Inhibitor

Tubastatin A hydrochloride is a potent histone deacetylase (HDAC) 6 inhibitor. HDAC6 exists exclusively in cytoplasm and deacetylates cytoplasmic proteins such as α-tubulin. Tubastatin A induces α-tubulin hyperacetylation, and may be a potential agent for the inhibition of tumor cell growth. Recently, it is considered that HDAC6 over-activation is associated with several pathological conditions in the central nervous system, such as Alzheimer's disease. Therefore, HDAC6 is a promising target for the treatment of neurological disorders.

References

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