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Sulindac
(CAS RN:38194-50-2 Product Number:U0099)

Structure

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Sulindac
Synonym (Z)-5-Fluoro-2-methyl-1-[(p-methylsulfinyl)benzylidene]-1H-indene-3-acetic Acid
Synonym (Z)-2-[5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl]acetic Acid

General Information

Product Number U0099

Availabe Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse.
Stock in other WH:2-3 Business Days
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Purity/Analysis Method >98.0%(HPLC)(T)
Grade
Storage Temperature
M.F. / M.W. C20H17FO3S=356.41
CAS RN 38194-50-2
Related CAS RN
MDL Number MFCD00599589
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 182.0 to 186.0 deg-C

Data of Reference

λmax 327(0.05mol/L methanolic HCl)(lit.)

References

PubChem SID 354334891
Merck Index(14) 8982
RTECS# NK8226000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H317
  • :May cause an allergic skin reaction.
  • H334
  • :May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H361
  • :Suspected of damaging fertility or the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P261
  • :Avoid breathing dust, fume, mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P272
  • :Contaminated work clothing must not be allowed out of the workplace.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P284
  • :Wear respiratory protection.
  • P301+P310+P330
  • :If swallowed: Immediately call a poison center or doctor. Rinse mouth.
  • P302+P352+P333+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation or rash occurs: Take off contaminated clothing. And wash it before reuse.
  • P304+P340+P342+P311
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. If experiencing respiratory symptoms: Call a poison center or doctor.
  • P308+P313
  • :If exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2811
Class 6.1
Packing Group III

Application

Sulindac: A Nonsteroidal Anti-Inflammatory Drug (NSAID) with Unique Metabolisms

U0099

Sulindac is a nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic activities. The mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. Sulindac is a unique prodrug. Slindac is reversibly metabolized to sulindac sulfide [S0906] which has anti-inflammatory and analgesic properties and is irreversibly metabolized to sulindac sulfone which has been suggested to possess antiproliferative effects against tumors. (The product is for research purpose only.)

References

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