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Heterobifunctional Cross-Linkers

 Bi-reactive compounds with different active groups at both termini of a linker are called "hetero"-crosslinkers. PEG and acyl (fatty) chains are primarily used as linkers to connect these two different active groups. Typical active groups include Carboxyl group or NHS (N-hydroxysuccinimide) for crosslinking to amines on the target molecule, Amine or Hydrazide against the carboxylic acid, Thiol (disulfide bond forming) and Maleimide for crosslinking thiol on the target molecule, etc. For covalently bonding amine and carboxylic acid, peptide bond (= amide bond) is formed by using EDC, CMC, DCC, DIC, and others as condensing agents. Heterobifunctional crosslinkers are used widely for bonding various biomolecules and small molecules. Crosslinkers are essential in drug discovery of biopharmaceuticals, ADC (Antibody-Drug Conjugates), PDC (Peptide-Drug Conjugates), DDS (Drug Delivery Systerms), as well as manufacturing of activated resins/beads and other applications.
A0648
2-Aminoethanethiol
A2293
11-Azido-3,6,9-trioxaundecanoic Acid
A2294
11-Azido-3,6,9-trioxaundecanol
A2363
11-Azido-3,6,9-trioxaundecan-1-amine
A2388
Azido-PEG4-NHS Ester
A2436
N-(2-Aminoethyl)maleimide Hydrochloride
A2500
14-Azido-3,6,9,12-tetraoxatetradecanol
A2526
1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic Acid
A2674
4-Azido-2,3,5,6-tetrafluorobenzoic Acid
A2729
5-Azidovaleric Acid
A2738
3-Azidopropylamine
A2763
Dibenzocyclooctyne-amine (This product is unavailable in the U.S.)
A3004
Azido-PEG4-Amine
A3007
Azido-PEG11-Amine
A3079
Azidoacetic Acid
A3120
2-[2-(2-Aminoethoxy)ethoxy]acetic Acid
A3224
8-Azido-3,6-dioxaoctanoic Acid Cyclohexylamine Salt
A3260
Azido-PEG4-C2-carboxylic Acid
B4062
N-(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyloxycarbonyl-1,8-diamino-3,6-dioxaoctane
B4472
N-(tert-Butoxycarbonyl)propargylamine
B4969
3-Butynoic Acid
B5587
tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
B5651
21-[(tert-Butoxycarbonyl)amino]-4,7,10,13,16,19-hexaoxaheneicosanoic Acid
B5665
(Boc-amino)-PEG4-carboxylic Acid
B5684
6-[(tert-Butoxycarbonyl)amino]hexanoic Acid N-Succinimidyl Ester
C2757
N-Carbobenzoxy-6-aminohexanoic Acid
D4580
Diethylene Glycol Mono(2-propyn-1-yl) Ether
D4739
Dibenzocyclooctyne-maleimide (This product is unavailable in the U.S.)
F0719
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
F1036
3-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-1-propanol
F1183
(Fmoc-amino)-PEG6-carboxylic Acid
F1238
(Fmoc-amino)-PEG12-C2-Carboxylic Acid
G0445
Glycidyl Propargyl Ether
G0458
Genipin
H0882
5-Hexynoic Acid
H1544
N-(2-Hydroxyethyl)maleimide
L0058
DL-α-Lipoic Acid
L0207
(R)-α-Lipoic Acid
L0314
Lipoamido-PEG12-carboxylic Acid
L0345
DL-α-Lipoic Acid-NHS
M0052
Thioglycolic Acid
M1962
3-Maleimidopropionic Acid
M2266
6-Mercapto-1-hexanol
M2337
4-Maleimidobutyric Acid
M2338
6-Maleimidohexanoic Acid
M2666
19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid
M2703
3-Maleimidopropiohydrazide Trifluoroacetate
M2735
6-Maleimidohexanehydrazide Trifluoroacetate
M3079
Maleimide-PEG2-NHS Ester
M3143
2-Maleimidoacetic Acid
M3203
Mal-PEG2-acid
N1119
NHS-PEG4-SPDP
P0911
Propargylamine
P2139
N-Propargylmaleimide
P2166
2-(2-Propynyloxy)ethylamine
P2225
2-[2-(2-Propynyloxy)ethoxy]ethylamine
P2283
Propargyl-PEG5-NHS Ester
P2341
4-Pentynoic Acid
P2668
3-(2-Pyridyldithio)propionic Acid
S0398
N-Succinimidyl 3-Maleimidobenzoate [Cross-linking Reagent]
S0399
N-Succinimidyl 4-Maleimidobutyrate [Cross-linking Reagent]
S0427
N-Succinimidyl 3-Maleimidopropionate [Cross-linking Reagent]
S0428
N-Succinimidyl 6-Maleimidohexanoate [Cross-linking Reagent]
S0812
N-Succinimidyl Methacrylate
S0814
N-Succinimidyl Acrylate
S0819
N-Succinimidyl 3-(2-Pyridyldithio)propionate
S0844
N-Succinimidyl Iodoacetate
S0852
N-Succinimidyl Bromoacetate
S0853
N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate
S0859
N-Succinimidyl 3-(Acetylthio)propionate
S0860
N-Succinimidyl 5-Azido-2-nitrobenzoate
S0861
N-Succinimidyl 4-(4-Maleimidophenyl)butyrate
S0863
N-Succinimidyl 4-Benzoylbenzoate
S0881
N-Succinimidyl 6-[[4-(N-Maleimidomethyl)cyclohexyl]carboxamido]hexanoate
S0882
N-Succinimidyl 11-Maleimidoundecanoate
S0883
3-Sulfo-N-succinimidyl 4-(N-Maleimidomethyl)cyclohexane-1-carboxylate Sodium Salt
S0893
N-Succinimidyl 4-Formylbenzoate
S0952
N-Succinimidyl 4-Azido-2,3,5,6-tetrafluorobenzoate
S0968
N-Succinimidyl Maleimidoacetate
S0973
N-Succinimidyl 4-(Azidosulfonyl)benzoate
T2818
4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzyl Alcohol
T2819
4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzyl Bromide
T2820
4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid
T3114
Triethylene Glycol Mono(2-propynyl) Ether
T3448
4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzylamine Hydrochloride
U0054
10-Undecynoic Acid
U0122
Sulfo-EMCS
U0124
Sulfo-KMUS

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