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3,5-Bis(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
(CAS RN:73852-19-4 Product Number:B1886)


3,5-Bis(trifluoromethyl)phenylboronic Acid
Synonym 3,5-Bis(trifluoromethyl)benzeneboronic Acid (contains varying amounts of Anhydride)

General Information

Product Number B1886

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Purity/Analysis Method
Storage Temperature
M.F. / M.W. C8H5BF6O2=257.93
CAS RN 73852-19-4
Related CAS RN
MDL Number MFCD00051850
Packaging and Container
  • Product Details
  • Safety & Regulations


Purity(Neutralization titration) 95.0 to 108.0 %


Reaxys-RN 7379990
PubChem SID 87564774


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2931399090


An Effective Amide Synthesis Using Boronic Acid–DMAPO Cooperative Catalysis

B1886 & D3220

Typical procedure (R1=PhEtCH, R2=Bn, R3=H): A 10 mL flask is charged with 2-phenylbutyric acid (82.1 mg, 0.5 mmol), 3,5-bis(trifluoromethyl)phenylboronic acid (6.5 mg, 5 mol%), and DMAPO hydrate (3.5 mg as anhydrous, 5 mol%) in fluorobenzene (0.2 M). After the mixture is stirred at ambient temperature for 5 min, benzylamine (53.6 mg, 0.5 mmol) is added. The resulting mixture is heated under azeotropic reflux conditions with the removal of water for 17 hours. After the reaction mixture is cooled to ambient temperature, the solvent is evaporated. The residue is purified by column chromatography on silica gel (eluent: hexane:EtOAc=4:1) to give N-benzyl-2-phenylbutanamide as a white solid (125.4 mg, 99% yield).


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