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Cyclophosphamide Monohydrate
(CAS RN:6055-19-2 Product Number:C2236)

Structure

Cyclophosphamide
Synonym 2-[Bis(2-chloroethyl)amino]tetrahydro-1,3,2-oxazaphosphorin-2-oxide Monohydrate

General Information

Product Number C2236

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Purity/Analysis Method >98.0%(N)
Storage Temperature 0-10°C
M.F. / M.W. C7H15Cl2N2O2P·H2O=261.08(as Anhydrous)
CAS RN 6055-19-2
Related CAS RN 50-18-0
MDL Number MFCD00149395
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(with Total Nitrogen) min. 98.0 %(calcd.on anh.substance)
Melting point 49.0 to 53.0 deg-C
Water max. 8.0 %

References

Reaxys-RN 8167897
PubChem SID 125307342
Merck Index(14) 2747
RTECS# RP6157750
EC Number 200-015-4

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
  • H315
  • :Causes skin irritation.
  • H340
  • :May cause genetic defects.
  • H350
  • :May cause cancer.
  • H362
  • :May cause harm to breast-fed children.
Precautionary Statements
  • P260
  • :Do not breathe dusts or mists.
  • P263
  • :Avoid contact during pregnancy/while nursing.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.

Transport Information

UN Number 3464
Class 6.1
Packing Group III
HS Number 2934999090

Application

Reagent for cystitis model

References

Reagent for hematopoietic disorder model

References

Reagent for overactive bladder model

References

Reagent for nausea or vomiting model

References

Reviews on the Pharmacology of Cyclophosphamide

References

  • An overview of cyclophosphamide and ifosfamide pharmacology
    • R. A. Fleming, Pharmacotherapy 1997, 17, 146S.
  • Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks
  • The chemistry of the metabolites of cyclophosphamide
    • S. M. Ludeman, Curr. Pharm. Des. 1999, 5, 627.
  • Mechanisms of resistance to the toxicity of cyclophosphamide
    • M. P. Gamcsik, M. E. Dolan, B. S. Andersson, D. Murray, Curr. Pharm. Des. 1999, 5, 587.

Optical resolution study

References

PubMed Literatures

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