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2'-Deoxy-5-fluorouridine
(CAS RN:50-91-9 Product Number:D2235)

Structure

2'-Deoxy-5-fluorouridine
Synonym 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
Synonym Floxuridine
Synonym 5-Fluoro-2'-deoxy-β-uridine
Synonym FUDR

General Information

Product Number D2235

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C9H11FN2O5=246.19
CAS RN 50-91-9
Related CAS RN
MDL Number MFCD00006530
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 150.0 to 153.0 deg-C
Specific rotation [a]20/D +35.0 to +40.0 deg(C=1, H2O)
Solubility in Water almost transparency

References

Reaxys-RN 90221
PubChem SID 87568673
Merck Index(14) 4112
RTECS# YU7525000
EC Number 200-072-5

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

UN Number 2811
Class 6.1
Packing Group III
HS Number 2934999090

Application

Floxuridine: An Antitumor Antimetabolite with Inhibition of Thymidylate Synthase

Floxuridine (FUDR), an antitumor antimetabolite, is a prodrug of 5-fluorouracil (5-FU) [F0151]. Floxuridine is rapidly catabolized to 5-FU in vivo. Similarly to 5-FU, floxuridine inhibits thymidilate synthetase (TS) which is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). dTMP forms thymidine, a nucleic acid in deoxyribonucleic acid (DNA). Therefore, the primary effect of floxuridine is to interfere with the synthesis of DNA. (The product is for research purpose only.)

References

PubMed Literature

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