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(CAS RN:372-48-5 Product Number:F0217)



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Product Number F0217

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Purity/Analysis Method >98.0%(GC)
Storage Temperature
M.F. / M.W. C5H4FN=97.09
CAS RN 372-48-5
Related CAS RN
MDL Number MFCD00006224
Packaging and Container
  • Product Details
  • Safety & Regulations


Appearance Colorless to Light orange to Yellow clear liquid
Purity(GC) min. 98.0 %

Data of Reference

flp 24°C(lit.)
bp 126°C


Beilstein 20(1)80
Reaxys-RN 1515
PubChem SID 87569997
EC Number 206-757-5


Signal Word Warning
Hazard Statements
  • H226
  • :Flammable liquid and vapour.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P210
  • :Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P403+P235
  • :Store in a well-ventilated place. Keep cool.

Transport Information

UN Number 1993
Class 3
Packing Group III
HS Number 2933399990


Transformation of Aliphatic and Aromatic Secondary Amides to Nitriles

Typical Procedure:
To an ice bath-cooled solution of a secondary amide (1.0 mmol) and 2-fluoropyridine (1.2 mmol) in anhydrous CH2Cl2 (5 mL) is added Tf2O (1.1 mmol). After being stirred for 0.5 h, the reaction mixture is warmed to 30 °C and stirred until completion of the reaction (monitored by TLC analysis). The reaction is quenched with 1 M HCl (1.0 mL), and the mixture is extracted with CH2Cl2 (3×10 mL). The combined organic layers are washed with saturated sodium carbonate (5 mL) and brine (5 mL), dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue is purified by column chromatography on silica gel (ethyl acetate/petroleum ether) to afford the corresponding nitrile.


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