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N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds]
(CAS RN:10416-59-8 Product Number:B0510)

Structure

N,O-Bis(trimethylsilyl)acetamide
Synonym BSA (25% in Acetonitrile)
Synonym TMS-BA (25% in Acetonitrile)

General Information

Product Number B0510

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Purity/Analysis Method
Storage Temperature 0-10°C
M.F. / M.W.
CAS RN 10416-59-8
Related CAS RN
MDL Number MFCD00008270
Packaging and Container 12mL-Vial (View image)
  • Product Details
  • Safety & Regulations

Specification

Appearance Colorless to Light yellow clear liquid
Effect test of TMS derivatization Effective as derivatization agent DL-Threonine

References

Reaxys-RN 1306669
PubChem SID 87563534
F&F 3,23
EC Number 233-892-7

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H225
  • :Highly flammable liquid and vapour.
  • H302
  • :Harmful if swallowed.
  • H311
  • :Toxic in contact with skin.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
  • H341
  • :Suspected of causing genetic defects.
  • H370
  • :Causes damage to Respiratory System, Central Nervous System.
  • H373
  • :May cause damage to Liver, Blood (System), Respiratory System, Kidney, Central Nervous System through prolonged or repeated exposure.
Precautionary Statements
  • P210
  • :Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
  • P260
  • :Do not breathe mist, vapours or spray.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P302+P352+P312+P361+P364
  • :IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or doctor if you feel unwell. Take off immediately all contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P308+P311
  • :If exposed or concerned: Call a POISON CENTER or doctor.

Transport Information

UN Number 1992
Class 3/6.1
Packing Group II
HS Number 2931399090

Application

Trimethylsilylating Reagent for GC Derivatization

B0510,B0691

Experimental procedure: ca. 1 mg of sample and 1 mL of TMS-BA is placed into a dry vessel (about 2 mL of vial is preferable). After sealing the vessel, the reaction is proceeded by shaking or heating (e.g. for leucine, threonine, by heating for 15 min at 125 °C) to result a transparent solution. And then it is directly injected into GC.

References

Reactivity of Trimethylsilylating Reagents : Trimethylsilylation of Alcohols

B0511, B0510, B0911, T0691

References

  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

PubMed Literature

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