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Chlorotrimethylsilane
(CAS RN:75-77-4 Product Number:C0306)

Structure

Chlorotrimethylsilane
Synonym TMCS
Synonym TMS-Cl
Synonym Trimethylchlorosilane
Synonym Trimethylsilyl Chloride

General Information

Product Number C0306

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Purity/Analysis Method >98.0%(GC)
Storage Temperature
M.F. / M.W. C3H9ClSi=108.64
CAS RN 75-77-4
Related CAS RN
MDL Number MFCD00000502
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Appearance Colorless to Light yellow to Light orange clear liquid
Purity(GC) min. 98.0 %

Data of Reference

flp -28°C(lit.)
mp -58°C(lit.)
bp 57°C

References

Beilstein 4(3)1857
Reaxys-RN 1209232
PubChem SID 87565458
F&F 10,96
RTECS# VV2710000
EC Number 200-900-5

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H225
  • :Highly flammable liquid and vapour.
  • H290
  • :May be corrosive to metals.
  • H301+H331
  • :Toxic by inhalation and if swallowed.
  • H312
  • :Harmful in contact with skin.
  • H314
  • :Causes severe skin burns and eye damage.
  • H371
  • :May cause damage to Respiratory System.
Precautionary Statements
  • P260
  • :Do not breathe mist, vapours or spray.
  • P301+P330+P331+P310
  • :IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or doctor.
  • P303+P361+P353+P310+P363
  • :IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a POISON CENTER or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor.
  • P305+P351+P338+P310
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor.
  • P370+P378
  • :In case of fire: Use dry chemical or dry sand to extinguish.

Transport Information

UN Number 1298
Class 3/8
Packing Group II
HS Number 2931399090

Application

Acetylation of Alcohols using Acetylating Reagents and Acid Catalysts

C0306

References

  • 1)A Simple Method for the Esterification of Carboxylic Acids Using Chlorosilanes
  • 2)Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

Trimethylsilylation of Alcohols using TMS Reagents

C0306

References

  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

Mono-TMS Protection of Diols using TMS Chloride and HMDS

C0306

References

  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

SMe Cleavage/Acetylation of MTM(Methylthiomethyl) Groups using Chlorotrimethylsilane

References

  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

Deprotection of MOM Groups using Chlorotrimethylsilane

References

  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

PubMed Literature

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