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(CAS RN:996-50-9 Product Number:T0492)


Synonym Diethylaminotrimethylsilane
Synonym TMS-DEA

General Information

Product Number T0492

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Purity/Analysis Method >98.0%(GC)
Storage Temperature
M.F. / M.W. C7H19NSi=145.32
CAS RN 996-50-9
Related CAS RN
MDL Number MFCD00009040
Packaging and Container
  • Product Details
  • Safety & Regulations


Appearance Colorless to Light yellow clear liquid
Purity(GC) min. 98.0 %

Data of Reference

flp 9°C(lit.)
bp 126°C


Reaxys-RN 635718
PubChem SID 87576427
F&F 6,634
EC Number 213-637-6


Signal Word Danger
Hazard Statements
  • H225
  • :Highly flammable liquid and vapour.
  • H314
  • :Causes severe skin burns and eye damage.
Precautionary Statements
  • P260
  • :Do not breathe dusts or mists.
  • P301+P330+P331+P310
  • :IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or doctor.
  • P303+P361+P353+P310+P363
  • :IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a POISON CENTER or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor.
  • P305+P351+P338+P310
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor.
  • P370+P378
  • :In case of fire: Use dry chemical or dry sand to extinguish.

Transport Information

UN Number 2733
Class 3/8
Packing Group II
HS Number 2931399090


Trimethylsilylating Reagent for GC Derivatization

Trimethylsilylation of Amino Acids1-4): 100 mol% excess of TMS-DEA (usually 1.5-2.0 mL) is added to a sample and is heated to reflux, which subsequently resulted in a transparent solution (it is preferable to remove the resulting diethylamine by distillation). After cooling, it is diluted with benzene to a proper concentration to use directly as a GC sample. If a catalytic amount of TMCS or trichloroacetic acid is added, better results are acquired. This method is also applicable to samples other than amino acids.


Trimethylsilylation of Alcohols using TMS Reagents



  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

PubMed Literature

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