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(CAS RN:91421-43-1 Product Number:A2063)



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Product Number A2063

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Purity/Analysis Method >95.0%(HPLC)
Storage Temperature
M.F. / M.W. C20H17N3O4=363.37
CAS RN 91421-43-1
Related CAS RN
MDL Number MFCD00909855
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Purity(HPLC) min. 95.0 area%


Reaxys-RN 4276593
PubChem SID 87560557
Merck Index(14) 431
RTECS# UQ0490500

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HS Number 2939790090


9-Aminocamptothecin (9-AC): A Water Insoluble Topoisomerase-I Inhibitor

9-Aminocamptothecin (9-AC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity, and a metabolite of 9-nitrocamptothecin [N0822]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.


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