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Almotriptan Malate
(CAS RN:181183-52-8 Product Number:A3111)

Structure

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Almotriptan Malate
Synonym 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indole Malate

General Information

Product Number A3111

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature
M.F. / M.W. C17H25N3O2S·C4H6O5=469.55
CAS RN 181183-52-8
Related CAS RN 154323-57-6
MDL Number MFCD08067740
Packaging and Container
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Specification

Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 8.50 to 9.50 %

References

Reaxys-RN 15435698
Merck Index(14) 304

Transport Information

HS Number 2935909099

Application

Almotriptan Malate: A Selective 5-HT1B/1D Receptor Agonist

Almotriptan malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, known as triptan. Almotriptan binds with high affinity to 5-HT1B, 5-HT1D, and 5-HT1F receptors, and has weak affinity for 5-HT1A and 5-HT7 receptors. However, almotriptan has no significant affinity at 5-HT2, 5-HT3, 5-HT4 or 5-HT6. Triptans, including almotriptan, are major advance in the treatment of migraine. The therapeutic activity of triptans in migramine can most likely to be attributed to agonist effects at 5-HT1B/1D receptors on the intracranial blood vessels. (The product is for research purpose only.)

References

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