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Bleomycin Sulfate (mixture)
(CAS RN:9041-93-4 Product Number:B3972)

Structure

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Bleomycin Sulfate

General Information

Product Number B3972

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Purity/Analysis Method >85.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W.
CAS RN 9041-93-4
Related CAS RN 11056-06-7
MDL Number MFCD00070310
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Appearance White to Orange to Green powder to crystaline
Purity(HPLC) min.85.0 area% (Sum of A2,B2)
BleomycinA2 55.0 to 70.0 area%
BleomycinB2 25.0 to 32.0 area%

References

PubChem SID 253659941
Merck Index(14) 1318
RTECS# EC5991990
EC Number 232-925-2

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H351
  • :Suspected of causing cancer.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents/container through a waste management company authorized by the local government.

Transport Information

HS Number 2941900000

Application

Reagent for pneumonitis model

References

Reagent for pulmonary fibrosis model

References

Bleomycin: A Glycopeptide Antitumor Antibiotics Agent

Bleomycin, a glycopeptide antitumor antibiotic agent, was first discovered in 1966 when the Japanese bacteriologist Umezawa found anticancer activity while screening culture filtrates of Streptomyces verticillus. Activated bleomycin (Fe-bleomycin-O2 complex), the active species, forms in the reaction of bleomycin with Fe(II) and O2. It also forms in the reaction of bleomycin with Fe(III) and peroxide, or bleomycin with superoxide and either Fe(III) or Fe(II). The activated bleomycin produces DNA strand break at 3'-4' bond in a deoxyribose sugar moiety. The mechanism of this bond cleavage reaction and the nature of the active oxidizing species are still open issues.

References

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