Home >   Products   >  Advanced Search

7-Ethylcamptothecin
(CAS RN:78287-27-1 Product Number:E0781)

Structure

7-Ethylcamptothecin

General Information

Product Number E0781

* Items available from stock in Japan will be delivered in 10 business days.
* Please contact us if you need further information.
(Sales Dept Tel: +32 (0)3 735 07 00 E-mail: Sales-EU@TCIchemicals.com)
* To send your quote request for bulk quantities, please click on the “Request Bulk Quotation” button. Please note that for some of our products we cannot offer bulk quantities.
* TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

Purity/Analysis Method >96.0%(HPLC)
Storage Temperature
M.F. / M.W. C22H20N2O4=376.41
CAS RN 78287-27-1
Related CAS RN
MDL Number MFCD06657922
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 96.0 area%
Specific rotation [a]20/D +40.0 to +46.0 deg(C=0.4, CHCl3:MeOH=8:2)

References

Reaxys-RN 4828556
PubChem SID 87561055

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301+H311+H331
  • :Toxic by inhalation, in contact with skin and if swallowed.
Precautionary Statements
  • P261
  • :Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P302+P352+P312+P361+P364
  • :IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or doctor if you feel unwell. Take off immediately all contaminated clothing and wash it before reuse.
  • P304+P340+P311
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or doctor.

Transport Information

UN Number 1544
Class 6.1
Packing Group III
HS Number 2939790090

Application

7-Ethylcamptothecin: A Water Insoluble Topoisomerase-I Inhibitor

7-Ethylcamptothecin (SN-22) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. 7-Ethylcamptothecin has been converted into water soluble derivatives such as irinotecan hydrochloride [I0714]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.

References

PubMed Literature

Page Top