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Epothilone B
(CAS RN:152044-54-7 Product Number:E1378)


Epothilone B

General Information

Product Number E1378

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Purity/Analysis Method >95.0%(HPLC)
Storage Temperature -20°C
M.F. / M.W. C27H41NO6S=507.69
CAS RN 152044-54-7
Related CAS RN
MDL Number MFCD02101921
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Purity(HPLC) min. 95.0 area%
Specific rotation [a]20/D -40.0 to -44.0 deg (C=0.2, methanol)
Elemental analysis(Carbon) 62.50 to 65.00 %

Data of Reference

mp 94°C(lit.)
[α]20D -36° (C=0.2,MeOH)(lit.)
λmax 249(MeOH)(lit.)


Reaxys-RN 7556514
Merck Index(14) 3628
RTECS# JG6799500


Epothilone B: A Microtubule Inhibitor

Epothilone B, a natural macrolide compound, is a microtubule inhibitor belonging to a class of antineoplastic agents. Epothilone B was originally isolated from the cellulose-degrading myxobacteria Sorangium cellulosum. Epothilone B has a mode of action analogous to that of paclitaxel [P1632]. It binds directly to β-tubulin subunits on microtubules, stabilizing microtubules. It blocks cells in the mitotic phase of the cell division cycle, leading to cell death. Epothilone B has poor metabolic stability and unfavorable pharmacokinetics.1-4) Therefore, its analogs (e.g. Ixabepilone; BMS-247550) were synthesized and used in clinical.4) (The product is for research purpose only.)


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