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9-Nitrocamptothecin
(CAS RN:91421-42-0 Product Number:N0822)

Structure

9-Nitrocamptothecin
Synonym Rubitecan

General Information

Product Number N0822

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature
M.F. / M.W. C20H15N3O6=393.36
CAS RN 91421-42-0
Related CAS RN
MDL Number MFCD06656294
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Specification

Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D +36.0 to +42.0 deg(C=0.4, CHCl3:MeOH=8:2)

Data of Reference

mp 268°C(lit.)

References

Reaxys-RN 5365063
PubChem SID 87560509
Merck Index(14) 8288

Transport Information

HS Number 2939790090

Application

9-Nitrocamptothecin (9-NC): A Water Insoluble Topoisomerase-I Inhibitor

9-Nitrocamptothecin (9-NC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. Its metabolite is 9-aminocamptothecin [A2063]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.

References

PubMed Literature

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