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Aminoguanidine Hydrochloride
(CAS RN:1937-19-5 Product Number:A1129)

Structure

Aminoguanidine Hydrochloride

General Information

Product Number A1129

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Purity/Analysis Method >98.0%(T)
Storage Temperature
M.F. / M.W. CH6N4·HCl=110.55
CAS RN 1937-19-5
Related CAS RN 79-17-4
MDL Number MFCD00039074
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity( Potassium iodate Method) min. 98.0 %
Melting point 161.0 to 167.0 deg-C

References

Reaxys-RN 3909606
PubChem SID 87562613
RTECS# ME8430000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2925.29.9000

Application

Two Biological Effects of Aminoguanidine Hydrochloride

It is reported that aminoguanidine hydrochloride has two important biological effects. Firstly, it is effective for the prevention of formation of advanced glycation endproducts (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging.1-3) Aminoguanidine hydrochloride reacts rapidly with in vivo glycation α,β-dicarbonyl products such as methylglyoxal, glyoxal [G0152], and 3-deoxyglucosone to prevent the formation of AGEs.
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine [ A0526]. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions. 3-6) (The product is for research purpose only.)

References

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