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1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis]
(CAS RN:530-62-1 Product Number:C0119)

Structure

1,1'-Carbonyldiimidazole
Synonym 1,1'-Carbonylbis-1H-imidazole
Synonym CDI

General Information

Product Number C0119

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Purity/Analysis Method >97.0%(T)
Storage Temperature 0-10°C
M.F. / M.W. C7H6N4O=162.15
CAS RN 530-62-1
Related CAS RN
MDL Number MFCD00005286
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Appearance White to Light yellow powder to crystal
Purity(Neutralization titration) min. 97.0 %
Melting point 114.0 to 121.0 deg-C

References

Beilstein 23(3/4)575
Reaxys-RN 6826
PubChem SID 87565300
Merck Index(14) 1819
F&F 9,96

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H314
  • :Causes severe skin burns and eye damage.
Precautionary Statements
  • P260
  • :Do not breathe dusts or mists.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P330+P331+P310
  • :If swallowed: Rinse mouth. Do NOT induce vomiting. Immediately call a poison center or doctor.
  • P303+P361+P353+P310+P363
  • :If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a poison center or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. Immediately call a poison center or doctor.
  • P305+P351+P338+P310
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center or doctor.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 1759
Class 8
Packing Group III
HS Number 2933.29.9000

Application

Condensation of Amino Acides Using 1,1’- Carbonyldiimidazole

Typical Procedure:
To a solution of N-Cbz-glycine (2.09 g, 0.010 mol) in dry THF (10 mL) is added 1,1’-carbonyldiimidazole (CDI) (1.62 g, 0.010 mol). After stirring for 1.5 hour, L-tyrosine ethyl ester (2.09 g, 0.010 mol) is added to the solution and the reaction mixture is stirred overnight. Then THF is removed by an evaporator and 1 N-HCl (50 mL) is added. Cooling of the solution gives a solid. This is washed with water and 5% NaHCO3. The solid is filtered and washed with water again. After drying, the product is recrystallized from 50% ethanol to give ethyl N-Cbz-glycine- L -tyrosine ethyl ester (3.79 g, yield 95%).

References

PubMed Literature

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