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(CAS RN:108-91-8 Product Number:C0494)



General Information

Product Number C0494

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Purity/Analysis Method >99.0%(GC)
Storage Temperature
M.F. / M.W. C6H13N=99.18
CAS RN 108-91-8
Related CAS RN
MDL Number MFCD00001486
  • Product Details
  • Safety & Regulations
  • Reference & Application


Purity(GC) min. 99.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Specific gravity (20/20) 0.8670 to 0.8690
Refractive index n20/D 1.4580 to 1.4600

Data of Reference

flp 30°C(lit.)
bp 135°C


Beilstein 12,5
Reaxys-RN 471175
PubChem SID 87565613
Merck Index(14) 2729
RTECS# GX0700000


Signal Word Danger
Hazard Statements
  • H226
  • :Flammable liquid and vapor.
  • H301+H311+H331
  • :Toxic by inhalation, in contact with skin and if swallowed.
  • H314
  • :Causes severe skin burns and eye damage.
  • H335
  • :May cause respiratory irritation.
  • H340
  • :May cause genetic defects.
  • H361
  • :Suspected of damaging fertility or the unborn child.
  • H370
  • :Causes damage to Nervous System, Cardiovascular System.
  • H402
  • :Harmful to aquatic life.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P210
  • :Keep away from heat, sparks, open flames and hot surfaces. – No smoking.
  • P233
  • :Keep container tightly closed.
  • P240
  • :Ground and bond container and receiving equipment.
  • P241+P242+P243
  • :Use explosion-proof electrical, ventilating and lighting equipment. Use only non-sparking tools. Take precautionary measures against static discharge.
  • P260
  • :Do not breathe mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P271
  • :Use only outdoors or in a well-ventilated area.
  • P273
  • :Avoid release to the environment.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P330+P331+P310
  • :If swallowed: Rinse mouth. Do NOT induce vomiting. Immediately call a poison center or doctor.
  • P303+P361+P353+P310+P363
  • :If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a poison center or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. Immediately call a poison center or doctor.
  • P305+P351+P338+P310
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center or doctor.
  • P307+P311
  • :If exposed: Call a poison center or doctor.
  • P403+P233
  • :Store in a well-ventilated place. Keep container tightly closed.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2357
Class 8/3
Packing Group II
HS Number 2921.30.5000


Synthesis of a Piperazine Derivative


Synthesis of 1-Cyclohexyl-4-tosylpiperazine
N,N-Bis[2-(p-tolylsulfonyloxy)ethyl]-p-toluenesulfonamide (B4136, 5.83 g, 10.3 mmol), K2CO3 (P1748, 8.00 g, 58.0 mmol), cyclohexylamine (C0494, 0.99 g, 10.0 mmol), and anhydrous CH3CN (50 mL) are added to a round-bottom flask. The mixture is heated to reflux under an N2 atmosphere for 12 h. The mixture is cooled to r.t. and filtered. The filtrate is concentrated, and the residue is purified by flash chromatography (SiO2, CH2Cl2-CH3OH-Et3N as eluent) to give 1-cyclohexyl-4-tosylpiperazine as a white solid in 83% yield (2.67 g).


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