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Cyclosporin A
(CAS RN:59865-13-3 Product Number:C2408)

Structure

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Cyclosporin A
Synonym Cyclosporin

General Information

Product Number C2408

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Purity/Analysis Method >97.0%(HPLC)(N)
Storage Temperature 0-10°C
M.F. / M.W. C62H111N11O12=1202.64
CAS RN 59865-13-3
Related CAS RN
MDL Number MFCD00274558
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 97.0 area%
Purity(with Total Nitrogen) min. 97.0 %
Specific rotation [a]20/D -185 to -193 deg(C=0.5, MeOH)

Data of Reference

mp 151°C(lit.)

References

Reaxys-RN 3647785
PubChem SID 125307331
Merck Index(14) 2752
RTECS# GZ4120000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H350
  • :May cause cancer.
  • H360
  • :May damage fertility or the unborn child.
  • H362
  • :May cause harm to breast-fed children.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P260
  • :Do not breathe dusts or mists.
  • P263
  • :Avoid contact during pregnancy or while nursing.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P312+P330
  • :If swallowed: Call a poison center or doctor if you feel unwell. Rinse mouth.
  • P308+P313
  • :If exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

HS Number 2941.90.1050

Application

Cyclosporin A: A Calcineurin Inhibitor with Immunosuppressive Properties

Cyclosporin A (CsA) is a cyclic polypeptide immunosuppressant, and was initially isolated from the fungus Tolypocladium inflatum Gams in 1970. Cyclosporin A is practically insoluble in water, soluble in diethyl ether, and very soluble in methanol, ethanol and acetonitrile. Cyclosporin A inhibits T-lymphocyte activation, although the exact mechanism of action is not known. Experimental evidence suggests that cyclosporin A is inactive by itself and requires binding to an intracellular protein, cyclophiline D (CypD), for activation in cells. A complex of CsA–CypD, calcium, calmodulin, and calcineurin (a calcium and calmodulin dependent protein phosphatase) is then formed and the phosphatase activity of calcineurin inhibited. This effect may prevent both T-lymphocyte signal transduction and IL-2 transcription. Tacrolimus (FK506) [M2258] is also inhibits calcineurin and is more potent than cyclosporin A. Cyclosporin A is mainly metabolized by cytochrome P 450 IIIA (CYP3A) subfamilies. (The product is for research purpose only.)

References

PubMed Literature

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