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Clotrimazole
(CAS RN:23593-75-1 Product Number:C2867)

Structure

Clotrimazole
Synonym 1-[(2-Chlorophenyl)diphenylmethyl]imidazole
Synonym 1-(2-Chlorotrityl)imidazole

General Information

Product Number C2867

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C22H17ClN2=344.84
CAS RN 23593-75-1
Related CAS RN
MDL Number MFCD00057220
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 144.0 to 148.0 deg-C

Data of Reference

λmax 556(Phosphate buffer sol.)(lit.)

References

Reaxys-RN 622318
PubChem SID 253661533
Merck Index(14) 2417
RTECS# NI4377000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P312+P330
  • :If swallowed: Call a poison center or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

HS Number 2933.29.2000

Application

Clotrimazole: A Synthetic Imidazole Antifungal and an IKCA Inhibitor

Clotrimazole is a chemical synthetic imidazole antifungal. It has in vitro strong activity against Candida species, Trichophyton species, Microsporum species and Malassezia furfur. Besides that, clotrimazole has some in vitro activity against certain Gram-positive bacteria. Clotrimazole works to kill individual Candida or fungal cells by altering the permeability of the fungal cell wall. In additon, clotrimazole shows therapeutic effects on sickle cell disease, and etc. by inhibiting membrane intermediate-conductance Ca2+-activated K+ channels (IKCa). (The product is for research purpose only.)

References

PubMed Literature

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