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(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Trimethylsilyl Ether
(CAS RN:848821-58-9 Product Number:D3843)


(S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol Trimethylsilyl Ether
Synonym α,α-Diphenyl-L-prolinol Trimethylsilyl Ether
Synonym (S)-(-)-2-[Diphenyl(trimethylsilyloxy)methyl]pyrrolidine
Synonym (S)-Hayashi-Jorgensen Catalyst

General Information

Product Number D3843

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Purity/Analysis Method >98.0%(GC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C20H27NOSi=325.53
CAS RN 848821-58-9
Related CAS RN
MDL Number MFCD08690083
  • Product Details
  • Safety & Regulations
  • Reference & Application


Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Specific gravity (20/20) 1.0430 to 1.0470
Refractive index n20/D 1.5480 to 1.5520
Specific rotation [a]20/D -48.0 to -53.0 deg(C=1, CHCl3)

Data of Reference

λmax 193(lit.)


Reaxys-RN 10089429
PubChem SID 354334880


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2933.99.8290


Organocatalysts for Asymmetric Michael Additional Reactions



Asymmetric Organocatalyst

Experimental procedure3): The β-ketoester 2 (0.2 mmol) is added to a solution of 3 (0.02 mmol), benzoic acid (0.02 mmol), and the aldehyde 1 (0.6 mmol) in toluene (0.2 mL). After complete consumption of 2, usually within 14–18 h, the crude product is directly charged on to silica gel and subjected to flash chromatography (hexane:Et2O) to afford 4.


PubMed Literature

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