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Gatifloxacin Hydrate
(CAS RN:614751-80-3 Product Number:G0325)


Synonym 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Hydrate

General Information

Product Number G0325

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C19H22FN3O4·xH2O=375.40(as Anhydrous)
CAS RN 614751-80-3
Related CAS RN 112811-59-3,180200-66-2
MDL Number
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Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 95.0 %(calcd.on anh.substance)
Melting point 180.0 to 184.0 deg-C
Water 4.5 to 9.0 %


PubChem SID 354335684

Transport Information

HS Number 2933.59.3600


Gatifloxacin: An 8-Methoxy Fluoroquinolone Antibacterial Agent with a Broad Antibacterial Spectrum

Gatifloxacin (AM-1155) is an 8-methoxy fluoroquinolone antibacterial agent with a 3-methylpiperazinyl substituent at C7. Fluoroquinolone fungicidal antibacterial agents are inhibitor of bacterial DNA gyrase and topoisomerase IV. 1,2) DNA gyrase is an essential enzyme that is involved in the replication, transcription, and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division. As just described, the mechanism of action of fluoroquinolones is different from the other antibiotics. Therefore, there is no cross-resistance between fluoroquinolones and the other classes of antibiotics. In particular, gatifloxacin has a broader spectrum of antibacterial activity than the older fluoroquinolones and shows good activity against many Gram-positive and Gram-negive bacteria, atypical organisms and some anaerobes. 3) Furthermore, gatifloxacin possesses a higher selectivity for bacterial type II topoisomerases.4) (The product is for research purpose only.)


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