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Imatinib
(CAS RN:152459-95-5 Product Number:I0906)

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Imatinib

General Information

Product Number I0906

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C29H31N7O=493.62
CAS RN 152459-95-5
Related CAS RN 220127-57-1
MDL Number MFCD05662257
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 97.0 %
Melting point 207.0 to 211.0 deg-C

References

Reaxys-RN 9300263
PubChem SID 253661909
Merck Index(14) 4902
RTECS# CV5585673

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
  • H361
  • :Suspected of damaging fertility or the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P308+P313
  • :If exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

HS Number 2933.59.5300

Application

Imatinib: A Tyrosine Kinase Inhibitor and a Molecular-Targeted Agent

Imatinib is a synthetic tyrosine (Tyr) kinase inhibitor and a molecular-targeted agent that specifically target several protein tyrosine kinases, such as stem-cell factor receptor (c-KIT), platelet-derived growth factor receptor (PDGF-R), and notably Bcr-Abl. Imatinib mesylate [I0936] is used in the treatment of chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. (The product is for research purpose only.)

References

PubMed Literature

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