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Lovastatin
(CAS RN:75330-75-5 Product Number:L0214)

Structure

Lovastatin
Synonym 6α-Methylcompactin
Synonym Mevinolin
Synonym Monacolin K

General Information

Product Number L0214

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature
M.F. / M.W. C24H36O5=404.55
CAS RN 75330-75-5
Related CAS RN
MDL Number MFCD00072164
  • Product Details
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  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D +320 to +340 deg(C=0.5, CH3CN)

Data of Reference

mp 179°C(lit.)

References

Reaxys-RN 4720754
PubChem SID 87560159
Merck Index(14) 5586
RTECS# EK7907000

Transport Information

HS Number 2922.50.1400

Application

Lovastatin: A Potent HMG-CoA Reductase Inhibitor

Lovastatin is a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. It was first isolated from in a fermentation broth of Aspergillus terreus in 1978, and taken into clinical development as potential agents for lowering LDL cholesterol. Lovastatin is an inactive lactone which is readily hydrolyzed in vivo to the corresponding active beta-hydroxy acid. The active acid inhibits the action of enzyme HMG-CoA reductase that catalyzes the rate-limiting step in cholesterol biosynthesis, resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. (The product is for research purpose only.)

References

HMG-CoA Reductase Inhibitors (Statins)

The products are for research purpose only.

References

PubMed Literature

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