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2-Methyl-5-nitroimidazole-1-ethanol
(CAS RN:443-48-1 Product Number:M0924)

Structure

2-Methyl-5-nitroimidazole-1-ethanol
Synonym Metronidazole

General Information

Product Number M0924

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Purity/Analysis Method >99.0%(GC)(T)
Storage Temperature
M.F. / M.W. C6H9N3O3=171.16
CAS RN 443-48-1
Related CAS RN
MDL Number MFCD00009750
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Appearance White to Orange to Green powder to crystal
Purity(GC) min. 99.0 %
Purity(Nonaqueous Titration) min. 99.0 %
Melting point 159.0 to 163.0 deg-C
Solubility in hot Methanol almost transparency

References

Reaxys-RN 611683
PubChem SID 87572910
Merck Index(14) 6157
RTECS# NI5600000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H351
  • :Suspected of causing cancer.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :If exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

HS Number 2933.29.9000

Application

Metronidazole: A Nitroimidazole Antibiotic against Protozoans and Anaerobic Bacteria

2-Methyl-5-nitroimidazole-1-ethanol (metronidazole) is a synthetic nitroimidazole antibiotic such as azomycin [N0891] and dimetridazole [D1564]. Metronidazole has a limited spectrum of activity that encompasses various protozoans and most Gram-negative and Gram-positive anaerobic bacteria. Metronidazole is bactericidal through toxic metabolites (hydroxyl radicals) which cause bacterial DNA strand breakage. Metronidazole is active against Helicobacter pylori, however resistance to metronidazole is high. Thus, the combination of lansoprazole [L0233] or omeprazole [O0359] (as a proton pump inhibitor), amoxicillin [A2099] and metronidazole is used for the eradication of Helicobacter pylori.

References

PubMed Literature

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