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Osmium Tetroxide (4% in Water)
(CAS RN:20816-12-0 Product Number:O0308)


Osmium Tetroxide
Synonym Osmium(VIII) Oxide (4% in Water)

General Information

Product Number O0308

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Purity/Analysis Method
Storage Temperature 0-10°C
M.F. / M.W. OsO4=254.23
CAS RN 20816-12-0
Related CAS RN
MDL Number MFCD00011150
  • Product Details
  • Safety & Regulations
  • Reference & Application


Concentration 4.0 to 4.4 %


PubChem SID 87558433
Merck Index(14) 6893
F&F 16,249
RTECS# RN1140000


Signal Word Danger
Hazard Statements
  • H314
  • :Causes severe skin burns and eye damage.
  • H332
  • :Harmful if inhaled.
  • H370
  • :Causes damage to Adrenal Gland, Kidney, Liver, Respiratory System, Spleen.
  • H372
  • :Causes damage to Respiratory System through prolonged or repeated exposure.
  • H373
  • :May cause damage to Adrenal Gland, Hematopoietic System, Kidney, Liver, Spleen through prolonged or repeated exposure.
Precautionary Statements
  • P260
  • :Do not breathe mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P271
  • :Use only outdoors or in a well-ventilated area.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P330+P331+P310
  • :If swallowed: Rinse mouth. Do NOT induce vomiting. Immediately call a poison center or doctor.
  • P303+P361+P353+P310+P363
  • :If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a poison center or doctor. Wash contaminated clothing before reuse.
  • P304+P340+P310
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. Immediately call a poison center or doctor.
  • P305+P351+P338+P310
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center or doctor.
  • P307+P311
  • :If exposed: Call a poison center or doctor.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2471
Class 6.1
Packing Group I
HS Number 2825.90.9000


Oxidation of 1,2-Diols (Criegee Oxidation)1)

Typical Procedure:
To a solution of olefine 1 (11.9 mg, 0.030 mmol) and DMAP (7.33 mg, 0.060 mmol, 2 eq.) in t-BuOH (100 µL) is added a solution of OsO4 (7.62 mg, 0.030 mmol, 1 eq.) in water (200 µL). The orange-red solution is stirred at rt for 5-10 min. Solid Na2SO3 (19 mg, 0.15 mmol, 5 eq.) is added. The resulting mixture is applied directly to preparative TLC (CHCl3 : MeOH : NH4OH = 25 : 10 : 1) and diol is collected by washing silica gel with a mixture of CHCl3 : MeOH = 2 : 1. Concentration under reduced pressure (< 25 ℃) affords the slightly unstable diol 2, which is dissolved in CH2Cl2 (2 mL). The solution then is cooled to -20 ℃ and AcOH (9.0 mg, 8.6 µL, 5 eq.) is added, followed by solid Pb(OAc)4 (11 mg, 0.025 mmol) in portions. TLC (CH2Cl2 : MeOH = 1 : 1 and 25 : 1) monitors the end of the reaction. The resulting yellow solution is stirred at -20 ℃ for 5-10 min, washed with water, saturated NaHCO3 and brine, dried over Na2SO4 and evaporated under reduced pressure to give 3 (8.5 mg, Y. 71%) of silica gel labile ketone as a yellow powder.


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