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PD 173074
(CAS RN:219580-11-7 Product Number:P2474)


PD 173074
Synonym 1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea

General Information

Product Number P2474

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Purity/Analysis Method >95.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C28H41N7O3=523.68
CAS RN 219580-11-7
Related CAS RN
MDL Number MFCD08705327
  • Product Details
  • Safety & Regulations
  • Reference & Application


Purity(HPLC) min. 95.0 area%
Elemental analysis(Nitrogen) 18.00 to 19.50 %

Data of Reference

mp 86°C(lit.)


Reaxys-RN 10130688
PubChem SID 354335228


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2933.59.8000


PD173074: A Selective VEGFR and FGFR Inhibitor

PD173074 is a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, and also a selective fibroblast growth factor receptor (FGFR) inhibitor. VEGF is a signalling protein that induces angiogenesis and endothelial cell proliferation and it plays an important role in regulating vasculogenesis. FGF is a carrier protein that regulates important biological processes including cell proliferation and differentiation during development and tissue repair. The human FGFR reportedly comprises of four family members, FGFR1, FGFR2, FGFR3 and FGFR4. Recently, the anti-tumor activities of PD173074, targeted neoangiogenesis and mitogenesis, have been reported. (The product is for research purpose only.)


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