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Ribavirin
(CAS RN:36791-04-5 Product Number:R0077)

Structure

Ribavirin
Synonym 1-(β-D-Ribofuranosyl)-1,2,4-triazole-3-carboxamide

General Information

Product Number R0077

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Purity/Analysis Method >98.0%(HPLC)(N)
Storage Temperature
M.F. / M.W. C8H12N4O5=244.21
CAS RN 36791-04-5
Related CAS RN
MDL Number MFCD00058564
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Specific rotation [a]20/D -33.0 to -37.0 deg(C=1, H2O)

References

Reaxys-RN 892462
PubChem SID 87559671
Merck Index(14) 8198
RTECS# XZ4250000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H360
  • :May damage fertility or the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :If exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

HS Number 2940.00.6000

Application

Ribavirin: A Ribonucleoside Analog with Antiviral Activity

Ribavirin, a ribonucleoside analog, shows antiviral activity against a variety of viruses both in vitro and in vivo. Although its mechanism of action remains unknown exactly, five distinct mechanisms have been proposed to explain the antiviral properties of ribavirin. These include both direct mechanisms (interference with RNA capping, RNA polymerase inhibition, lethal mutagenesis) and indirect mechanisms (inosine monophosphate dehydrogenase inhibition, immunomodulatory effects). Ribavirin is widely used in combination with interferon-α (IFN-α) to treat hepatitis C virus infection. The addition of ribavirin greatly improves IFN-α responses. (The product is for research purpose only.)

References

PubMed Literature

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