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Rosiglitazone
(CAS RN:122320-73-4 Product Number:R0106)

Structure

Rosiglitazone

General Information

Product Number R0106

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C18H19N3O3S=357.43
CAS RN 122320-73-4
Related CAS RN
MDL Number MFCD00871760
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 154.0 to 158.0 deg-C

References

Reaxys-RN 7082202
PubChem SID 253659589
Merck Index(14) 8265
RTECS# XJ5813850

Transport Information

HS Number 2934.99.4400

Application

Rosiglitazone: An Agonist at the Peroxisome Proliferator-Activated Receptor of the Gamma Subtype (PPARγ)

Rosiglitazone, a thiazolidinedione, is an agonist at the peroxisome proliferator-activated receptor of the gamma subtype (PPARγ), a transcription-regulating receptor. PPAR receptors are found in peripheral tissues important for insulin action. Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. Therefore, rosiglitazone decreases insulin resistance in the periphery tissues and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. And recently, it has been reported that rosiglitazone is associated with cardiovascular problems. (The product is for research purpose only.)

References

PubMed Literature

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